A. Samaunnisa, Riazuddin Mohammed, C. Venkataramana
Oct 13, 2013
Citations
0
Influential Citations
2
Citations
Quality indicators
Journal
International research journal of pharmacy
Abstract
Novel 2,6 - dimethyl - N3 , N5 - diphenyl - 1,4 - dihydropyridine - 3,5 - dicarbohydrazide ( 2A - 2D’ ) and its derivatives were synthesized from Diethyl - 2,6 - dimethyl - 1,4 dihydrop yridine - 3,5 - dicarboxylates (1A) and Diethyl - 4 - (4 - hydroxyphenyl) - 2,6 - dimethyl - 1,4 - dihydropyridine - 3,5 - dicarboxylates ( 1A ’ ) . A set of 8 new derivatives (2A - 2D’), were subjected to i n vivo anti - inflammatory and analgesic activities . Anti - inflammatory activity was performed by using Carrageenan induced paw edema method and analgesic activity was performed by Eddy 's hot plate method . The obtained results were tabulated and represented graphically using histogram. Activity of all the derivatives was compared with th e chosen standards namely indomethacin and tramadol for anti - inflammatory and analgesic activity respectively , us ing dimethyl sulfoxide ( DMSO ) as control . Almost all the derivatives of the class exhibited significant activit y.