I. Bozkurt, K. Pepe, Mehmet Özdemi̇r
Apr 4, 2011
Citations
1
Influential Citations
5
Citations
Quality indicators
Journal
Scientific Research and Essays
Abstract
The effect of Methenolone Enanthate (ME), one of the Anabolic-Androgenic Steroids (AAS), used as a muscle amplifier and for doping by athletes, on the femur bone development of adolescent male and female rats has been researched in this study. Three different groups for each male and female rat, including 8 rats of each, (ME, V, C) were formed and a total of 48 rats were used. The subject groups were given 0.5 mg/kg methenolone enanthate (PrimobolanO Depot, Bayer) dilued in peanut oil, 0.5 ml; all animals received five intraperitonal injections weekly for four weeks. The rats were euthanized at the end of the four weeks and both femurs dissected and macerated. The length, corpus thickness, compact bone thickness and medulla canal diameter were measured with calipers and the average of each was noted. The effect of ME administration on femur length and corpus femoris thickness was negative in male animals but positive in females and was determined to be statistically significant (p 0.05), while a significant difference (p<0.05) had been seen between the sexes in medulla diameter in the control groups. It was concluded that, the ME effect on rat femurs, similar to that of other AAS, consists in supressing bone growth in male animals while enhancing in females during pubertas. Rat models show negative middle-term and long-term effects of this agent, which is still widely in use as a performance enhancer, as opposed to its positive results in the short term.