Gulhan Kocaman
Jan 22, 2020
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
Medical Science and Discovery
Abstract
Benzydamine hydrochloride (HCl) is an analgesic and NS antiinflammatory drug that can be used systemically and topically. The mechanism of antiinflammatory action of benzydamine HCl is achieved by blocking the biosynthesis of prostaglandins produced as an early response to tissue trauma by inhibition of arachidonic acid and cyclooxygenase enzyme. In addition, anti-inflammatory activity is achieved by mild inhibition of prostaglandin synthesis and strong inhibition of proinflammatory cytokines. Thus, TNF-α, IL-1β and MCP-1 (such as monocyte chemoattractant protein) cytokines can be classified as a suppressive anti-inflammatory (4). As a result of these effects, it stabilizes the cell membrane and reduces vascular permeability. resolves edema (5). Abstract