O. Lee, J. A. Mears, D. Miller
Sep 1, 1974
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0
Influential Citations
22
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Quality indicators
Journal
European journal of pharmacology
Abstract
Abstract The adrenoceptive properties of tetrahydroisoquinoline (THI) stereoisomers were evaluated in rat adipose tissue and guinea pig aorta, in vitro. The rank order of lipolytic activity observed for the more potent S-(−)-isomers of the THI's tested was trimetoquinol > 1-benzyl-6,7-dihydroxy-1,2,3,4-THI > tetrahydropapaveroline > salsolinol. The stereoisomers of trimetoquinol and racemic 1-benzyl-6,7-dihydroxy-1,2,3,4-THI were found to be equally active as competitive antagonists of noradrenaline-induced contraction of guinea pig aortic strips.