Ji-Sun Shin, Tae Woo Kim, Kyung Ju Kim
Feb 20, 2012
Citations
0
Influential Citations
9
Citations
Journal
Bulletin of The Korean Chemical Society
Abstract
The synthetic procedures and reaction conditions for 3phenyl-4-(4-sulfonamido)-1H-pyrrole-2,5-dione 2l are shown in Scheme 1: 4-Chlorosulfonylphenylacetic acid (4) was prepared from the reaction of phenylacetic acid (3) with ClSO3H, and then treated with SOCl2 and subsequent NH3 gas in CH3CN to provide 4-chlorosulfonylphenylacetamide (5), which was condensed with ethyl benzoylformate (2) using NaH condition to yield 3-(4-sulfamoylphenyl)-4phenyl-1H-pyrrole-2,5-dione (2l). 8