Lynn D. Condreay, R. Jansen, T. Powdrill
Mar 1, 1994
Citations
0
Influential Citations
40
Citations
Quality indicators
Journal
Antimicrobial Agents and Chemotherapy
Abstract
A murine model was developed to investigate the in vivo activity of anti-hepatitis B virus (HBV) agents. Mice with subcutaneous tumors of HBV-producing 2.2.15 cells showed reductions in levels of HBV in serum and in intracellular levels of HBV when the mice were orally dosed with (-) cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine (FTC). No effects on tumor size or alpha-fetoprotein levels were observed. FTC can selectively inhibit HBV replication at nontoxic doses.