J. Aubert, G. Ailhaud, R. Négrel
Nov 11, 1996
Citations
2
Influential Citations
42
Citations
Journal
FEBS Letters
Abstract
Prostacyclin, one of the major prostanoids generated in adipose tissue, has been previously described as an autocrine/ paracrine adipogenic effector, acting, in preadipose cells, by means of cAMP and free Ca2+ as cell surface receptor‐mediated messengers. The present study presents evidence for the first time that its stable analogue, carbaprostacyclin, is unique among prostanoids in regulating the expression of two differentiation‐dependent genes in preadipose and adipose cells in a way distinct from that elicited by its cell surface receptor. This regulation is likely mediated by some member(s) of the peroxisome proliferator‐activated receptor family and suggests that prostacyclin behaves as an intracrine effector of adipose cell differentiation.