Sang-Uk Kang, W. J. Choi, S. Oishi
Mar 20, 2007
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0
Influential Citations
6
Citations
Journal
Journal of medicinal chemistry
Abstract
A 4-aminopiperidine-4-carboxylic acid residue was placed in the pTyr+1 position of a Grb2 SH2 domain-binding peptide to form a general platform, which was then acylated with a variety of groups to yield a library of compounds designed to explore potential binding interactions, with protein features lying below the betaD strand. The highest affinities were obtained using phenylethyl carbamate and phenylbutyrylamide functionalities.