M. Elam, Z. E. Zadeh, S. Hooshmand
Apr 1, 2011
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Quality indicators
Journal
The FASEB Journal
Abstract
The use of ferutinin (jaeschkeanadiol p‐hydroxybenzoate), the main component of Ferula genus (giant fennel), especially from the roots of the Ferula hermonis is documented in the traditional medicine of the Mediterranean region. This plant has long been used to treat menopausal symptoms and impotency in men. The preventive role of ferutinin in ovariectomy‐induced bone loss has also recently been reported. The purpose of the present study is to determine the anabolic effects of ferutinin on bone using osteoblast‐like cells (MC3T3‐E1). Thus far, we have shown that the doses of ferutinin as high as 10−6 mol/L have no toxic effects on these cells. Other parameters that are being assessed include: calcium nodule formation and alkaline phosphatase activity, a marker of bone formation. Furthermore, this study intends to assess the mechanisms by which ferutinin increases nodule bone formation. Upon positive findings of this study, we will explore the bone forming ability of ferutinin in reversal of bone mass in other models of osteoporosis.