B. Trofimov, L. V. Andriyankova, L. Nikitina
May 1, 2010
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0
Influential Citations
10
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Journal
Synthesis
Abstract
The three-component reaction of a benzimidazole with an α,β-acetylenic γ-hydroxy nitrile and water in acetonitrile at 20-25 °C for seven days or at 45-50 °C for six hours results in cleavage of the imidazole ring to afford the corresponding (2-{[(3E)-5-aminofuran-3(2H)-ylidene]amino}phenyl)formamide exclusively in 84-99% yield. The synthesis involves multipositional cascade transformations of the intermediate hemiaminals formed from the primary zwitterions and water.