H. Fischer
Mar 1, 1965
Citations
1
Influential Citations
54
Citations
Journal
Radiology
Abstract
Iodipamide, the one intravenous cholangiographic agent in present use, is certainly of great value, although room for improvement in visualization of the bile ducts still exists. Too often the ducts are so faintly visualized as not to permit optimal study or no opaque material is seen at all. Poor or unrecognized liver function can be blamed for some failures, but better cholangiography might be sought in a knowledge of the normal pharmacology of iodipamide and attempts to enhance the biliary excretion of this agent. Precise information on the excretion of iodinated substances into the bile is meager, and there has been relatively little interest in modifying biliary excretion of contrast agents. Measurements of iodipamide in blood, bile, and urine in the dog over a range of intravenous doses is the subject of this paper. Iodipamide was originally introduced as the disodium salt of N, Nadipyl-bis (3-amino-2, 4, 6 triiodobenzoic acid), supplied as a 20 per cent solution. More recently the methylglucamine s...