M. Gons, J. D. Vijlder, T. Can-Bos
Feb 1, 1978
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Influential Citations
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Journal
Pediatric Research
Abstract
Iodohistidines were found in urines of patients with congenital goiter with abnormal iodoproteins (see also Savoie et al'). They were not detectable in urine of patients with other types of congenital goiter, carcinoma or thyroiditis. Iodohistidines originated from proteolysis of abnormal iodoproteins in the gland and were formed independently of the presence of thyroglobulin, which only contained traces of iodohistidines residues. We examined members of three families of patients with goiter and abnormal iodoproteins. Iodohistidines were found in the urine of one of the parents of each family. These parents were euthyroid, had no goiter or complaints, but goiter was common in their family.We suggest that the determination of iodohistidines in urine can be of great help for the diagnosis of a certain type of hereditary congenital thyroidal disorder.J.C.Savoie, J.P. Massin and F. SavoieJ.Clin.Invest. 52: 116, 1973.