J. Dawson, E. Mcchesney, F. Teller
Nov 1, 1968
Citations
0
Influential Citations
16
Citations
Journal
Acta Radiologica
Abstract
Isopaque-300 is a solution of metrizoic acid (3-acetamido-2,4,6-triiodo5[N-methylacetamido]-benzoic acid) in a balanced mixture of sodium, calcium, magnesium and N-methylglucamine salts. (Isopaque is a registered trade name of Winthrop Laboratories, New York, U.S.A. Metrizoic acid was first prepared in the laboratories of Nyegaard and Company, Oslo, Norway.) The concentrations of these salts in the order named are 43, 1.5, 0.5, and 7.9 %. This composition provides an organic iodine content of 300 mg/rnl, with a specific gravity of 1.31 (Winthrop Laboratories 1966). Metrizoic acid has been extensively studied as the sodium salt, in both laboratory and clinic. Its toxicity for the mouse has been found by BUSFIELD et coll, (1962) to be about equal to that of diatrizoate, but other studies in the Winthrop Laboratories have shown the animal toxicity of the Isopaque-300 formulation (based on equivalent amounts of iodine administered) to be about 70 % of that of sodium diatrizoate. Although studies in man (PATTINSON 1962, AMUNDSEN 1965) have indicated little difference in tolerance between diatrizoate and metrizoate, when these compounds were administered as the sodium salts or as mixtures of sodium and N-methylglucaminesalts, PATTINSON felt there were some overall advantages in favor of metrizoate. In a com-