Sonam Bhatia, Yogesh J. Malkhede, P. Bharatam
Jul 5, 2013
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0
Influential Citations
27
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Journal
Journal of Computational Chemistry
Abstract
N‐(Pyridin‐2‐yl)thiazol‐2‐amine is a versatile chemical functional unit present in many therapeutically important species. Quantum chemical analysis shows that there are six competitive isomeric structures possible for this class of compounds within a relative energy difference of ∼4 kcal/mol. Some of the isomeric structures possess divalent N(I) character. There appears to be a competition between the thiazole and pyridine groups to accommodate the tautomeric hydrogen, and consequently show electron donating property in the structure with R‐N←L representation. Details of electron distribution, tautomeric preferences, protonation energy, and divalent N(I) character, and so on, of this class of compounds are presented in this article. Subsequently, upon protonation, (L→N←L)⊕ character is clearly evident in these moieties as molecular orbital analysis clearly shows two lone pairs of electrons on the central nitrogen, in this system. © 2013 Wiley Periodicals, Inc.