Z. Ji
1990
Citations
0
Influential Citations
0
Citations
Quality indicators
Journal
The Chinese Journal of Clinical Pharmacology
Abstract
EPA (enpiperate) is developing for new antiepileptic,antitremous drug. On requirements of clinical pharamacological andtoxicological studies on new drugs. We have done some physical depen-dence-producing tests in mice and monkeys. The experiment in mice: i.p EPA, phenobarbital sodium (PBS) anddiazepam (DZP), twice a day or drinking water containing EPA or PBSat equal effective dosage for 4 weeks. After abrupt withdrawal of thedrug, 24 hours later, the mouse was put into audiogenic box to induceaudiogenic seizure (AS) individually, or ip. Pentylenetetrazole(PTZ) toinduce PTZ(+). The AS(+) or PTZ(+) rate of PBS and DZP are verysignificant from EPA or control group (P0 .01). There 's no differentbetween EPA and control group. Experiment in monkeys: i.g EPA 5mg/kg, and phenobarbital (PB)35mg/kg, or i .m EPA 2mg/kg, PBS 25mg/kg, twice a day, at first week.Then gradually increased dosage every week for 6-8 weeks. After with-drawal of drug, EPA-monkeys show no abstinent syndrome during two we-eks observational period. While PB, PBS-monkeys have mild, intermediateand severe degrees of withdrawal symptoms. Such as: apprehension, hyper-irritability, restlessness: anorexia, piloerection, tremor, muscle rigidity,impaired moter activity, nausea, boby weight lost, covulsion, dyspnea,failure. Large dosage of EPA cannot substitute for PB in monkegs.