Pavel K. Mykhailiuk, S. Shishkina, O. Shishkin
Apr 29, 2011
Citations
0
Influential Citations
22
Citations
Journal
Tetrahedron
Abstract
Abstract The synthesis of proline analogues bearing a fluorine-containing substituent at the fifth position of the pyrrolidine ring, racemic trans - and cis -5-fluoromethyl prolines, was performed. The key step of the synthesis is a transformation of the CH 2 OH-group into the CH 2 F-one using morpholinosulfur trifluoride. During the synthesis, an efficient procedure to prepare trans - and cis -5-fluoropipecolic acids was elaborated.