Chang Shu-Cheng, E. Gil-av, R. Charles
Apr 1, 1984
Citations
0
Influential Citations
15
Citations
Journal
Journal of Chromatography A
Abstract
Abstract The present scope of application of chiral hydrogen-bonding gas chromatographic phases to the resolution of various classes of optical isomers is briefly reviewed. A recent extension of this approach to the separation of the enantiomers of α-halogenocarboxylic acids via their tert.-butyl amides is then reported. The phases employed were diamides, R1CONHCH(R2)CONHR3, derived from L -alanine, L -leucine and L -proline. Best peak resolution was obtained on N-lauroyl- L -proline tert.-butylamide. In four cases peak assignment was made, and the order of elution was found to be D - before the L -isomer on L -phases. This behaviour is assumed to be valid for closely related members of the series and can serve for the determination of the configuration of unknowns. The analytical procedures developed are of particular interest for the study of stereospecific reactions involving α-halogenocarboxylic acids.