Sushil Kumar, B. V. Babu
Apr 29, 2009
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Journal
Journal of Chemical & Engineering Data
Abstract
Pyridine-3-carboxylic acid (also known as nicotinic acid) is widely used in food, pharmaceutical, and biochemical industries. The production of acid can be intensified by enzymatic conversion of 3-cyanopyridine or biosynthesis and by reactive extraction used as a separation step from a dilute fermentation broth. The extraction of pyridine-3-carboxylic acid by 1-dioctylphosphoryloctane, also known as tri-n-octylphosphine oxide (TOPO), with five different diluents (n-octane, methylbenzene, 4-methyl-2-pentanone (MIBK), decan-1-ol, and dichloromethane) is studied. The equilibrium experiments are carried out to investigate the effects of diluent, extractant (TOPO) composition, and initial acid concentration on extraction efficiency. The extraction efficiency is found to increase with increasing TOPO composition concentration, (0.10 to 0.60) mol·m−3, and found to decrease with increasing initial acid concentration, (0.02 to 0.12) mol·m−3. The number of TOPO molecules in the acid:TOPO complex is estimated throug...