T. Mohamed, Praveen P. N. Rao
Dec 9, 2015
Citations
0
Influential Citations
6
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The amination of quinazoline-based heterocyclics is of significant interest due to its privileged structure and application in the development of bioactive compound libraries, as well as in the synthesis of readily convertible building blocks. The current approaches generally result in low yields, utilize harsh conditions, and/or rely on expensive catalysts. After examining three different approaches to synthesize N4-monosubstituted quinazolin-2,4-diamines, we developed an efficient and mild synthetic method to prepare quinazolin-2,4-diamines in 80–85% yields.