Lifang Lai, Huanhuan Wang, Jie Wu
Apr 1, 2014
Citations
0
Influential Citations
4
Citations
Journal
Tetrahedron
Abstract
Abstract 1-(4-Haloisoquinolin-1-yl)ureas are generated efficiently via a tandem reaction of 2-alkynylbenzaldoxime, carbodiimide, with halide in water. The process involves the generation of halonium ion in situ by employment of NaI/oxone or NaBr/oxone as the promoters. This green process proceeds smoothly and efficiently, accommodating a variety of substituents to generate the desired products.