Y. Kitade, R. Nakanishi, M. Sako
Jul 25, 1991
Citations
0
Influential Citations
7
Citations
Journal
Chemical & Pharmaceutical Bulletin
Abstract
Facile conversion of N6-benzoyl-2', 3'-O-isopropylideneadenosine (1) into N6-benzoyl-5'-chloro-5'-deoxy-8-hydroxy-2', 3'-O-isopropylideneadenosine (3) by a reaction with cupric chloride in acetonitrile provides a new method for the chemical modification of adenosines. This reflects the prominent substitutent effect of N6-benzoyl group on the chemical reactivity of adenosines.