R. Aryan, Masoomeh Nojavan, F. Sadeghi
Sep 30, 2015
Citations
0
Influential Citations
5
Citations
Journal
Phosphorus, Sulfur, and Silicon and the Related Elements
Abstract
GRAPHICAL ABSTRACT Abstract A series of novel 4-phenylsulfonamido-6-aryl-2-phenylpyrimidine-5-carbonitrile derivatives have been synthesized through a two-step process. This protocol includes a facile surfactant-mediated methodology for the synthesis of 4-amino-6-aryl-2-phenylpyrimidine-5-carbonitrile derivatives through a one-pot, three-component reaction in the presence of a catalytic amount of cetyltrimethylammonium bromide in water. No additional organic solvents and oxidants were used. The pyrimidine-5-carbonitrile products were then subjected to a direct sulfonylation of 4-amino group to 4-phenylsulfonamide-6-aryl-2-phenylpyrimidine-5-carbonitrile derivatives in the presence of sodium hydride in tetrahydrofuran solution. These new structures were confirmed by 1H- and 13CNMR spectroscopy as well as mass spectrometry and elemental analyses.