A. V. Raghava Reddy, Garaga Srinivas, Chandiran Takshinamoorthy
Oct 18, 2015
Citations
1
Influential Citations
8
Citations
Journal
Scientia Pharmaceutica
Abstract
This paper describes the facile synthesis of sildenafil citrate (1) and its related compounds through an improved chlorosulfonation reaction using chlorosulfonic acid and thionyl chloride. This synthesis results in pure sildenafil with high yield. The structures of the compounds were determined with infrared (IR), 1H-NMR and 13C-NMR spectroscopic methods, and high resolution mass spectroscopy (HRMS) analysis.