Z. Ge, Qin Li, Shaohui Zheng
Mar 1, 2006
Citations
0
Influential Citations
5
Citations
Journal
Chinese Journal of Chemistry
Abstract
Ethyl 3-alkyl-4-hydroxy-2-thioxothiazolidine-4-carboxylates were prepared in excellent yields from the reaction of corresponding primary amines with carbon disulfide and ethyl 3-bromo-2-oxopropanoate in the presence of anhydrous potassium phosphate in DMF at room temperature within 1 h. The structures of the highly functionalized products were corroborated spectroscopically (IR, 1H NMR, 13C NMR, EI-MS) and by elemental analyses. A plausible mechanism for such type of cyclization was proposed.