T. Tsunoda, Kaori Uemoto, Chisato Nagino
Oct 8, 1999
Citations
0
Influential Citations
27
Citations
Journal
Tetrahedron Letters
Abstract
Abstract Some new Mitsunobu reagents, especially N,N,N′,N′ -tetramethylazodicarboxamide (TMAD)-tributylphosphine (TBP) and cyanomethylenetrimethylphosphorane (CMMP), mediated the direct transformation of primary and secondary alcohols into the corresponding nitriles in the presence of acetone cyanohydrin. This type of cyanation process can convert 3β-cholestanol to 3α-cyanocholestane in high yield with complete Walden inversion.