Vincent Leroy, George E. Lee, Jiang Lin
Jan 26, 2001
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Influential Citations
11
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Journal
Organic Process Research & Development
Abstract
Pre-clinical evaluation of a potential antipsychotic agent required a convenient synthesis of 3-(1-piperazinyl)-1H-indazole derivatives. Improvements of the original preparation provided a five-step sequence to an unsubstituted piperazine intermediate, with a 67% overall yield. All intermediates were isolated by filtration.