Xiang Ke-xu
2014
Citations
0
Influential Citations
0
Citations
Journal
Journal of Southwest China Normal University
Abstract
9-Fluorenyl structural unit is fundamental intermediates and essential biologically active fragment,and the functionalization of 9-Fluorenyl is crucial in the drug molecule conversion.Herein a practical method of reductive amination of 9-fluorenone has been reported in this paper.A high yield conversion(95%)has been achieved from 9-fluorenone to 9-fluorenone oxime under optimal condition;furthermore,9H-Fluoren-9-amine has been obtained by Zn reduction process with a medium yield for the first time,which is much better than reported in literature.This novel method provides a useful synthetic procedure with simple operation and low cost,which also exhibits high commercial value.