D. Ewing, C. Len, G. Mackenzie
Dec 15, 2000
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0
Influential Citations
24
Citations
Journal
Tetrahedron-asymmetry
Abstract
Abstract 1,2-O-Isopropylidene-α- d -xylofuranose has been used to protect one aldehyde group of o-phthalaldehyde. This chiral protecting group acts as a resolving agent and this leads to separable diastereoisomers when a new stereogenic centre is created by the conversion of the second aldehyde group to a benzyloxyhydroxyethyl chain. These separated diastereoisomers were cyclised to 1,3-dihydrobenzo[c]furans with retention of chiral integrity at the C3 site thus allowing further elaboration to enantiomerically pure nucleoside analogues.