Y. Horiguchi, Masayoshi Nakamura, A. Kida
Mar 1, 2003
Citations
0
Influential Citations
15
Citations
Journal
Heterocycles
Abstract
A synthesis of 1,1-disubstitued 1,2,3,4-tetrahydro-β-carbolines (13) was achieved in a highly effective manner via the trifluoroacetic acid catalyzed Pictet-Spengler reaction of the keto imines (9) prepared from tryptamine (8) with acyclic and cyclic ketones using titanium(IV) isopropoxide as the imination reagent under one pot procedure. This reaction provides a convenient and general method for preparing various 1,2,3,4-tetrahydro-β-carbolines derivatives.