A. Moormann, C. Yen, S. Yu
Oct 1, 1987
Citations
0
Influential Citations
17
Citations
Journal
Synthetic Communications
Abstract
Abstract A synthesis of 2-aminonicotinaldehyde (1) which does not require chromatography and is easily scaled up has been developed. Bromination of 2-amino-3-picoline, protected as a phthalimide (4), produced the gem-dibromide (5), which was reacted with Nh4OH. The imine intermediate (7) was hydrolyzed with acid, producing (1) in a 56% conversion from 4.