S. Mal, K. Prathap, Stephen C. Smith
May 27, 2015
Citations
0
Influential Citations
15
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A facile and expedient one pot synthesis of 8-chloro-[1,2,4]triazolo[4,3- a ]pyrazine derivatives from 2-chloro-3-hydrazinylpyrazine and aldehydes is described using chloramine T trihydrate as a safe and convenient electrocyclisation (oxidising) agent. The presence of the chloro group on pyrazine enabled us to access versatile new synthetic scaffolds by easy diversification using palladium catalysed Suzuki–Miyaura and Sonogashira cross coupling reactions. The products are obtained in high yields in short reaction time under mild conditions without the need for chromatographic purification.