N. M. Gandikota, R. S. Bolla, I. K. Viswanath
2017
Citations
0
Influential Citations
4
Citations
Journal
Asian Journal of Chemistry
Abstract
Pyrolo, imidazoand triazolo pyridines belonging to class of N-bridge head 5,6-bicyclic heterocycles are important motifs in bio-medicinal chemistry due to their good SAR (structureactivity relationship). Among them s-triazolo(4,3-a)pyridine ring system (I) that has been known since several years but to which meager attention has been paid. An effort was initiated to develop the synthesis amido aminomethyl fused triazoles (II) that would be compatible with amino acid substrates and polar functional groups. A wide range of research was going on these derivatives because of their interesting biological activities like antimicrobial [1], antiviral [1], anticonvulsant [1], antifungal [1], anticancer [1], antiallergic [2], herbicide activity [3], antioxidants [1]. These fused triazoles with general formula I are specially shows gastrointestinal [4] and chemotherapeutic activity [4-6] due to their outstanding effectiveness against a wide range of micro-organisms, such as, Staphylococcus aureus, Escherichia coil, Proteus mirabilis, Pseudomonas aeruginosa and Streptococcus pyogenes. These derivatives are used in the treatment of schistosomiasis [7] a typical disease found in Egypt. These 1,2,4-triazolo[4,3-a]pyridine derivatives have a considerable effect on glutamate [8,9]. This helps us to cure neurological and psychiatric disorders, which are associated with glutamate dysfunction. Triazolopyridines are found in A Facile Synthesis of Amide Derivatives of [1,2,4]Triazolo[4,3-a]pyridine