Anna S. Komendantova, K. A. Ivanova, Konstantin V. Lyssenko
2019
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Abstract
Novel 2-carboxamide-substituted 1,3,4-thiadiazines and 5,6-dihydro-4 H -1,3,4-thiadiazin-5-ols were synthesized by the reaction of oxamic acid thiohydrazides with phenacyl bromides. This reaction was performed using an equimolar mixture of thiohydrazide and α-bromoacetophenones in methanol under basic conditions. The ratio of products obtained in the cyclocondensation was found to be strongly dependent on the substitution pattern and reaction conditions.