M. Idrees, S. Kola, N. Siddiqui
Dec 30, 2019
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Quality indicators
Journal
Oriental journal of chemistry
Abstract
In the present research we have reported simple efficient synthesis technique to afford a novel series of 3-(5-(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)-N-aryl-[1,2,4]triazolo[3,4-b][1,3,4] thiadiazol-6-amine (4a-g) derivatives obtained by one pot cyclocondensation reaction of 5-(5(benzofuran-2-yl)-1-phenyl-1H-pyrazol-3-yl)-4-amino-4H-1,2,4-triazole-3-thiol (3) with substituted aryl isothiocyanate in DMF and K2CO3, without formation undesirable side products by simple work up procedure. The structures yielded (4a-g) were established by 13CNMR, IR, 1HNMR, elemental analysis and mass spectra. Entire synthesised compounds were screened for their In vitro biological assay via microorganism Gram-positive and Gram-negative bacterial strains at different concentrations. The bioassay revealed that some of the compounds have promising antimicrobial activities when compared with standard drug Chloramphenicol.