Qianyi Chen, C. Yuan*
Mar 6, 2008
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Influential Citations
3
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Journal
Synthesis
Abstract
The addition of the dianion derived from 2-oxophosphonates to chiral N-( TERT-butylsulfinyl)ketimines or -aldimine under mild reaction conditions afforded 4-( TERT-butylsulfinylamino)-2-oxoalkylphosphonates with good to excellent diastereoselectivity. The latter was then converted into an enantiopure 5,5-disubstituted 2-(dimethoxyphosphoryl)pyrrolidin-3-one via an intramolecular N-H insertion. Subsequent Horner-Wadsworth-Emmons reaction gave the corresponding 2-benzylidene derivatives.