G. Baccolini, C. Boga, C. Delpivo
Apr 6, 2011
Citations
0
Influential Citations
28
Citations
Journal
Tetrahedron Letters
Abstract
Abstract A series of hydantoins and thiohydantoins have been synthesized in water at room temperature from urea (or N -methylurea, or thiourea) and simple aldehydes (as glyoxal, and its simple derivatives) in the presence of phosphoric anhydride. The reaction time is 10 min using an equimolar amount of P 4 O 10 with respect to the other reagents, but the reaction occurs also, even if with longer reaction times, with very small amounts of P 4 O 10 . In addition, this method provides a clean and ‘green’ approach to hydantoins, compounds of great interest in biological and pharmacological fields.