Dawei Qi, Huaiyuan Zhang, Jia Tang
May 3, 2010
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Journal
Journal of Physical Chemistry C
Abstract
In this work, we reported an alternative strategy to the synthesis of core−shell structure Fe3O4@C@Au magnetic microspheres by a self-assembly approach. The as-synthesized Fe3O4@C@Au magnetic microspheres were functionalized with 4-mercaptophenylboronic acid and successfully applied for selective enrichment of glycopeptides and glycoproteins. At first, the Fe3O4@C magnetic microspheres were synthesized by two-step reactions including solvothermal and hydrothermal reactions. Then, Fe3O4@C@Au magnetic microspheres with core−shell structure were obtained by a self-assembly approach. Finally, the Fe3O4@C@Au magnetic microspheres were modified with 4-mercaptophenylboronic acid. The 4-mercaptophenylboronic acid-modified Fe3O4@C@Au magnetic microspheres were successfully applied to selective enrichment of glycoproteins and glycopeptides.