Yan Zhou, Ren-Jun Li, Xiaolong Wang
Nov 23, 2016
Citations
0
Influential Citations
0
Citations
Journal
Chemical Research in Chinese Universities
Abstract
A facile and highly efficient method has been developed for the synthesis of unsymmetrical N-aryl-2,2-di(1H-indol-3-yl)acetamide derivatives by regioselective Friedel-Crafts alkylation of the N-aryl-2-hydroxy-2-(1H-indol-3-yl) acetamide derivatives with various indoles catalyzed by 2 mol/L H2SO4 at room temperature in a short reaction time, the yield was up to 94%.