Norio Sakai, N. Uchida, T. Konakahara
May 19, 2008
Citations
0
Influential Citations
64
Citations
Journal
Tetrahedron Letters
Abstract
Abstract The combination of 5 mol % Cu(OTf)2 and CuCl in the presence of DMAP effectively catalyzed a three-component coupling reaction involving an alkynylsilane, an o-hydroxybenzaldehyde derivative, and a secondary amine. The reaction proceeded via intramolecular 5-exo-dig cyclization, resulting in direct synthesis of the corresponding benzofuran derivatives in moderate to excellent yields.