S. Vasoya, M. Patel, S. V. Dobaria
Feb 1, 2005
Citations
0
Influential Citations
6
Citations
Journal
ChemInform
Abstract
2-Hydrazinocarbonyl-3-chloro-5-phenoxybenzo[b]thiophene 1 has been prepared by the condensation of 3-chloro-5-phenoxybenzo[b]thiophenoyl chloride with hydrazine hydrate. Compound 1 on condensation with aromatic aldehyde furnishes 2-substituted benzalhydrazinocarbonyl-3-chloro-5-phenoxybenzo[b]thiophenes 2a-1, which on further cyclocondensation with chloroacetyl chloride in the presence of triethyl amine afford 4-aryl-3-chloro-1-(3'-chloro-5'-phenoxy-2'-benzo[b]thiophenoylamino)-2-azetidinones 3a-1. Compounds 2a-1 on reaction with acetic anhydride yield 2-(3'-chloro-5'-phenoxybenzo[b]thiophene-2'-yl)-4-acetyl-5-aryl-4,5-dihydro-1,3,4-oxadiazoles 4a-1. The structures of the compounds 2a-1, 3a-1 and 4a-1 have been confirmed by elemental analysis and IR, 1 H NMR and mass spectral data. All the compounds have been screened for their antitubercular activity towards Mycobacterium tuberculosis H 3 7 Rv and antimicrobial activity against different microbes.