R. El-Sayed
May 4, 1999
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Journal
ChemInform
Abstract
Abstract N-Benzyl-p-chloro and N-Benzyl-2,4-dichlorobenzamide react with hlorosulfonic acid to give the corresponding p-sulfonyl chlorides (1,19), which condensed with nucleophiles to give amino acid derivatives (–7) and (20–25). Some of the corresponding methyl esters (8–11) were prepared. Hydrazinolysis of these methyl esters yielded the hydrazides (12–15). Coupling reactions of some amino acid derivatives with amino acid methyl ester hydrochloride in THF-Et3N medium using the dicyclohexylcarbodiimide method furnishes the desired dipeptide methyl esters (16-18, 26-28). Some spectral data are briefly discussed.