K. Kanie, K. Mizuno, M. Kuroboshi*
Aug 15, 1998
Citations
0
Influential Citations
49
Citations
Journal
Bulletin of the Chemical Society of Japan
Abstract
Trifluoromethylamines are easily synthesized from dithiocarbamates by a reagent system consisting of tetrabutylammonium dihydrogentrifluoride and an N-halo imide under mild conditions. When this reaction was applied to dithiocarbamates ArN(R)CS2Me at higher temperatures, the trifluoromethylation was accompanied by halogen substitution at the p-position of the Ar group. The synthesis of trifluoromethyl-substituted adenosine is also described.