Feng‐Ying Xiang, Cui-fen Lu, Gui-chun Yang
Mar 1, 2008
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Journal
Chinese Journal of Chemistry
Abstract
An efficient and short route to synthesize pyrido[3,2-d]pyrimidinediones was achieved using poly(ethylene glycol) as a soluble polymeric support and phase transfer catalyst. The poly(ethylene glycol) (PEG) was reacted with 2,3-pyridinedicarboxylic anhydride to give PEG-bound ester 1, which was transformed into corresponding PEG-bound acyl azide 2. Then the PEG-supported acyl azide 2 was rearranged, reacted with a series of amines and spontaneously cycled to give product 5 in 84%–88% overall yields.