Y. Yuasa, Y. Yuasa, H. Tsuruta
Feb 1, 1998
Citations
0
Influential Citations
4
Citations
Journal
Synthetic Communications
Abstract
Abstract (S)-3-tert-Butoxycarbonylamino-1-nitro-2-oxo-4-phenylbutan 4 was converted to (2R, 3S)-1-amino-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutane 5a by a catalytic hydrogenation, or NaBH4-TiCl4 reduction followed by hydrogenation in favorable diastereoselectivity, a component of the HIV protease inhibitor VX-478.