Y. Rho, H. Ko, H. Sin
Jun 20, 2000
Citations
0
Influential Citations
5
Citations
Journal
ChemInform
Abstract
for theeffective construction of tetracyclic skeleton in anthracycli-none. In this paper, we synthesized idarubicinone (14) usingthe Friedel-Crafts acylation of preformed bicyclic AB-ringsynthon 5 with D-ring phthaloyl chloride (9). For this target,our AB-synthon was prepared from α-tetralone (2) by thesequence depicted in Scheme 1. α-Tetralone (2), which isprepared from 1,4-dimethoxybenzene and succinic anhy-dride via the Haworth synthesis,