Yuanhong Liu, F. Song, Liqing Cong
Jul 28, 2005
Citations
0
Influential Citations
39
Citations
Journal
The Journal of organic chemistry
Abstract
Efficient synthetic approaches to stereodefined (Z)-enynols have been developed through zirconium-mediated cross-coupling reactions of three different components involving alkyne, ketone, and alkynyl bromide in a one-pot procedure. The subsequent electrophilic cyclization of a wide variety of (Z)-enynols affords fully substituted (Z)-5-(1-iodoylidene)-2,5-dihydrofurans with high regio- and stereoselectivity under mild reaction conditions.