B. A. Cook, J. Sinnhuber, P. Thomas
Jun 28, 2006
Citations
2
Influential Citations
17
Citations
Quality indicators
Journal
Cancer
Abstract
Indicine N‐oxide, a pyrrolizidine alkaloid, was given to a five‐year‐old boy with refractory acute myelocytic leukemia. Three days after receiving the drug the patient developed signs and symptoms of acute hepatic failure. The patient died nine days after receiving the drug and an autopsy showed massive hepatic necrosis. The acute hepatic failure observed in this patient may have been secondary to indicine N‐oxide toxicity. Cancer 52:61‐63, 1983.