N. P. Sen, D. Smith, C. Moodie
1975
Citations
0
Influential Citations
6
Citations
Quality indicators
Journal
Food and cosmetics toxicology
Abstract
Simultaneous administration of diethylamine hydrochloride (2 or 4 g/litre) and sodium nitrite (0·4 or 0·8 g/litre) in the drinking-water to guinea-pigs for a period of up to 30 months failed to induce any tumours in the experimental animals. However, 18 of 20 guinea-pigs given diethylnitrosamine (15mg/litre) in the drinking-water developed liver tumours within 1 yr. None of the controls or animals receiving only the amine (4 g/litre) or nitrite (0·8 g/litre) developed liver tumours. The data suggest that the amount of in vivo synthesis of diethylnitrosamine from the ingested amine and nitrite occurring in the stomachs of the animals was insufficient to induce cancer in the animals within the experimental period. The strong basicity of diethylamine was probably responsible for the low in vivo yields of diethylnitrosamine.