E. Kool, Pete Crisalli, Ke Min Chan
Feb 21, 2014
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0
Influential Citations
58
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Journal
Organic Letters
Abstract
Hydrazones and oximes are widely useful structures for conjugate formation in chemistry and biology, but their formation can be slow at neutral pH. Kinetics studies were performed for a range of structurally varied hydrazines, and a surprisingly large variation in reaction rate was observed. Structures that undergo especially rapid reactions were identified, enabling reaction rates that rival orthogonal cycloaddition-based conjugation chemistries.