Xie Hong-ping, Xu Nai-yu, Ling Yi-lin
2006
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Journal
Chinese Journal of Hospital Pharmacy
Abstract
OBJECTIVE To establish an analytical method for the fast and simultaneous determinations of the three effective components contained in the compound clorprenaline bromhexine capsules.METHODS Based on the near infrared diffuse reflectance spectra,the multivariate calibration models of the three effective components were established using the partial least squares method.RESULTS For the calibration models of the three effective components clorprenaline hydrochloride,bromhexine hydrochloride and decloxizine hydrochloride,the correlation coefficients were(0.998 6),(0.998 6) and(0.998 6), respectively;the recovery ratios were(97.80%)-(100.78%),(98.65%)-(103.96%) and(98.12%)-(100.34%),respectively.CONCLUSION The method is accurate and reliable,and it can be applied to the fast and simultaneous determinations for the capsules.